The subunit composition of human extracellular superoxide dismutase (EC-SOD) regulate enzymatic activity
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چکیده
منابع مشابه
Human extracellular superoxide dismutase (EC-SOD) expression in transgenic chicken
Extracellular superoxide dismutase (EC-SOD) is a metalloprotein and functions as an antioxidant enzyme. In this study, we used lentiviral vectors to generate transgenic chickens that express the human EC-SOD gene. The recombinant lentiviruses were injected into the subgerminal cavity of freshly laid eggs. Subsequently, the embryos were incubated to hatch using phases II and III of the surrogate...
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WINNING ABSTRACT: Tobacco smoke contains a high concentration of oxidants and is the primary cause of chronic obstructive pulmonary disease (COPD). Extracellular superoxide dismutase (EC-SOD) is the major antioxidant enzyme in the extracellular space of the lung and is part of the lung defense against these oxidants. We hypothesized that EC-SOD is a risk factor for COPD. We found that EC-SOD pl...
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The antioxidant enzyme extracellular superoxide dismutase (EC-SOD) is abundant in the lung and is known to limit inflammation and fibrosis following numerous pulmonary insults. Previous studies have reported a loss of full-length EC-SOD from the pulmonary parenchyma with accumulation of proteolyzed EC-SOD in the airspace after an interstitial lung injury. However, following airspace only inflam...
متن کاملSubunit structure of human superoxide dismutase.
A subunit structure for human superoxide dismutase has been demonstrated by sedimentation equilibrium, agarose gel filtration, and sodium dodecyl sulfate polyacrylamide gel electrophoretic studies. This protein appears to be composed of 2 subunits, not linked by covalent bonds, each with a molecular weight about 16,000. Dissociation of the subunits is facilitated by alkylation of the two sulfhy...
متن کاملExtracellular Superoxide Dismutase
Extracellular-superoxide dismutase is a tetrameric copper-containing glycoprotein that previously has been demonstrated to be the major superoxide dismutase of human extracellular fluids. The occurrence of this enzyme in various human tissues that were removed from two accidental death victims and in 19 different human cultured cell lines was determined. All investigated tissues were found to c...
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ژورنال
عنوان ژورنال: BMC Biochemistry
سال: 2007
ISSN: 1471-2091
DOI: 10.1186/1471-2091-8-19